› 1f6a

X-ray diffraction
3.5Å resolution

Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)

Released:
DOI: 10.2210/pdb1f6a/pdb
PDB entry 1f6a coloured by chain, front view.
PDB entry 1f6a coloured by chain, side view.
PDB entry 1f6a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.
Garman SC, Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS
Nature 406 259-66 (2000)
PMID: 10917520

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134794 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (7 distinct):
High affinity immunoglobulin epsilon receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 20.32 KDa
Source organism: Homo sapiens
Expression system: HI-5 INSECT CELLS
UniProt:
  • Canonical: P12319 (Residues: 26-201; Coverage: 76%)
Gene names: FCE1A, FCER1A
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin heavy constant epsilon Chains: B, D
Molecule details ›
Chains: B, D
Length: 222 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: HI-5 INSECT CELLS
UniProt:
  • Canonical: P01854 (Residues: 211-427; Coverage: 40%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand SO4 5 x SO4
Ligand CPS 5 x CPS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: R32
Unit cell:
a: 192.8Å b: 192.8Å c: 302.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.254 0.273
Expression system: HI-5 INSECT CELLS

Quick links

Citations

61 review citations

The impact of glycosylation on the biological function and structure of human immunoglobulins.
Arnold et al. (2007)
60 more

18 mentions without citation

Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions.
Lefranc et al. (2020)
17 more