› 1f8z

Solution NMR

NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR

Released:
DOI: 10.2210/pdb1f8z/pdb
PDB entry 1f8z coloured by chain, ensemble of 20 models, front view.
PDB entry 1f8z coloured by chain, ensemble of 20 models, side view.
PDB entry 1f8z coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities.
Clayton D, Brereton IM, Kroon PA, Smith R
FEBS Lett 479 118-22 (2000)
PMID: 10981718

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01130 (Residues: 234-272; Coverage: 5%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Structure determination by Torsion angle dynamics, Molecular dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

Structure and physiologic function of the low-density lipoprotein receptor.
Jeon et al. (2005)
2 more

3 mentions without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)
2 more