› 1fcy

X-ray diffraction
1.3Å resolution

ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARBETA/GAMMA-SELECTIVE RETINOID CD564

Released:
DOI: 10.2210/pdb1fcy/pdb
PDB entry 1fcy coloured by chain, front view.
PDB entry 1fcy coloured by chain, side view.
PDB entry 1fcy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
Klaholz BP, Mitschler A, Moras D
J Mol Biol 302 155-70 (2000)
PMID: 10964567

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13631 (Residues: 182-417; Coverage: 52%)
Gene names: NR1B3, RARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 564 1 x 564
Ligand LMU 1 x LMU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P41212
Unit cell:
a: 59.849Å b: 59.849Å c: 155.158Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.133 0.164
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Principles for modulation of the nuclear receptor superfamily.
Gronemeyer et al. (2004)
14 more

7 mentions without citation

Ligand Identification Scoring Algorithm (LISA).
Zheng et al. (2011)
6 more