› 1ff1

Solution NMR

STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL

Released:
DOI: 10.2210/pdb1ff1/pdb
PDB entry 1ff1 coloured by chain, ensemble of 20 models, front view.
PDB entry 1ff1 coloured by chain, ensemble of 20 models, side view.
PDB entry 1ff1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of NPF recognition by EH domains.
de Beer T, Hoofnagle AN, Enmon JL, Bowers RC, Yamabhai M, Kay BK, Overduin M
Nat Struct Biol 7 1018-22 (2000)
PMID: 11062555

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154666 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor substrate 15 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42566 (Residues: 121-215; Coverage: 11%)
Gene names: AF1P, EPS15
Structure domains: EF-hand
PTGSSSTNPFL PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

12 review citations

Biological basket weaving: formation and function of clathrin-coated vesicles.
Brodsky et al. (2001)
11 more

2 mentions without citation

Predicting the disruption by UO2(2+) of a protein-ligand interaction.
Pible et al. (2010)
1 more