› 1fkf

X-ray diffraction
1.7Å resolution

ATOMIC STRUCTURE OF FKBP-FK506, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX

Released:
DOI: 10.2210/pdb1fkf/pdb
PDB entry 1fkf coloured by chain, front view.
PDB entry 1fkf coloured by chain, side view.
PDB entry 1fkf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J
Science 252 839-42 (1991)
PMID: 1709302

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand FK5 1 x FK5
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P42212
Unit cell:
a: 58.07Å b: 58.07Å c: 55.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 not available
Expression system: Not provided

Quick links

Citations

60 review citations

Protein folding in the cell.
Gething et al. (1992)
59 more

27 mentions without citation

Cheminformatics in Natural Product-based Drug Discovery.
Chen et al. (2020)
26 more