› 1fn1

X-ray diffraction
1.6Å resolution

CRYSTAL STRUCTURE OF 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CG(5BR)UACG)2

Released:
DOI: 10.2210/pdb1fn1/pdb
PDB entry 1fn1 coloured by chain, front view.
PDB entry 1fn1 coloured by chain, side view.
PDB entry 1fn1 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)(2).
Adams A, Guss JM, Collyer CA, Denny WA, Wakelin LP
Nucleic Acids Res 28 4244-53 (2000)
PMID: 11058124

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113816 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(P*GP*(BRO)UP*AP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 5 nucleotides
Theoretical weight: 1.58 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*CP*GP*(BRO)UP*AP*CP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 6 nucleotides
Theoretical weight: 1.87 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CO 2 x CO
Ligand 8AD 1 x 8AD
1 modified residue:
Ligand BRU 2 x BRU

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: C222
Unit cell:
a: 28.88Å b: 53.168Å c: 40.416Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.24
Expression system: Not provided

Quick links

Citations

3 review citations

Non-G Base Tetrads.
Escaja et al. (2022)
2 more

4 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
3 more