› 1fqq

Solution NMR

SOLUTION STRUCTURE OF HUMAN BETA-DEFENSIN-2

Released:
DOI: 10.2210/pdb1fqq/pdb
PDB entry 1fqq coloured by chain, ensemble of 20 models, front view.
PDB entry 1fqq coloured by chain, ensemble of 20 models, side view.
PDB entry 1fqq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment.
Sawai MV, Jia HP, Liu L, Aseyev V, Wiencek JM, McCray PB, Ganz T, Kearney WR, Tack BF
Biochemistry 40 3810-6 (2001)
PMID: 11300761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin beta 4A Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15263 (Residues: 24-64; Coverage: 100%)
Gene names: DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B
Sequence domains: Beta defensin
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing, torsion angle dynamics
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

Defensins: antimicrobial peptides of innate immunity.
Ganz T. (2003)
16 more

6 mentions without citation

Peptide antimicrobial agents.
Jenssen et al. (2006)
5 more