› 1fzv

X-ray diffraction
2Å resolution

THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION

Released:
DOI: 10.2210/pdb1fzv/pdb
PDB entry 1fzv coloured by chain, front view.
PDB entry 1fzv coloured by chain, side view.
PDB entry 1fzv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M, Tucci M, Persico MG, Acharya KR
J Biol Chem 276 12153-61 (2001)
PMID: 11069911

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Placenta growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 132 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49763 (Residues: 19-144; Coverage: 62%)
Gene names: PGF, PGFL, PLGF
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P43
Unit cell:
a: 62.6Å b: 62.6Å c: 84.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.247
Expression system: Escherichia coli

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Citations

19 review citations

Vascular endothelial growth factor (VEGF) signaling in tumor progression.
Roskoski R. (2007)
18 more

11 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
10 more