› 1g9o

X-ray diffraction
1.5Å resolution

FIRST PDZ DOMAIN OF THE HUMAN NA+/H+ EXCHANGER REGULATORY FACTOR

Released:
DOI: 10.2210/pdb1g9o/pdb
PDB entry 1g9o coloured by chain, front view.
PDB entry 1g9o coloured by chain, side view.
PDB entry 1g9o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains.
Karthikeyan S, Leung T, Birrane G, Webster G, Ladias JA
J Mol Biol 308 963-73 (2001)
PMID: 11352585

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 91 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14745 (Residues: 11-99; Coverage: 25%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P3221
Unit cell:
a: 51.568Å b: 51.568Å c: 58.947Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.181 0.201
Expression system: Escherichia coli BL21(DE3)

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Citations

9 review citations

Molecular aspects of renal anionic drug transport.
Russel et al. (2002)
8 more

18 mentions without citation

Assembly, structure, and function of the 26S proteasome.
Bedford et al. (2010)
17 more