› 1gj2

Solution NMR

CO(III)-BLEOMYCIN-OOH BOUND TO AN OLIGONUCLEOTIDE CONTAINING A PHOSPHOGLYCOLATE LESION

Released:
DOI: 10.2210/pdb1gj2/pdb
PDB entry 1gj2 coloured by chain, front view.
PDB entry 1gj2 coloured by chain, side view.
PDB entry 1gj2 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage.
Hoehn ST, Junker HD, Bunt RC, Turner CJ, Stubbe J
Biochemistry 40 5894-905 (2001)
PMID: 11352724

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113870 (preferred)
Entry contents:
3 distinct DNA molecules
Macromolecules (3 distinct):
5'-D(*CP*CP*AP*AP*AP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.8 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(P*AP*CP*TP*GP*GP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 6 nucleotides
Theoretical weight: 1.85 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*CP*CP*AP*GP*TP*AP*CP*TP*TP*TP*GP*G)-3' Chain: C
Molecule details ›
Chain: C
Length: 13 nucleotides
Theoretical weight: 3.94 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

5 bound ligands:
Ligand PGA 1 x PGA
Ligand 3CO 1 x 3CO
Ligand O 1 x O
Ligand BLB 1 x BLB
Ligand PEO 1 x PEO
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

7 review citations

Noncovalent interactions with DNA: an overview.
Strekowski et al. (2007)
6 more

2 mentions without citation

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors.
Jeddi et al. (2017)
1 more