› 1glp

X-ray diffraction
1.9Å resolution

1.8 ANGSTROMS MOLECULAR STRUCTURE OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS

Released:
DOI: 10.2210/pdb1glp/pdb
PDB entry 1glp coloured by chain, front view.
PDB entry 1glp coloured by chain, side view.
PDB entry 1glp coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors.
García-Sáez I, Párraga A, Phillips MF, Mantle TJ, Coll M
J Mol Biol 237 298-314 (1994)
PMID: 8145243

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.5 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P19157 (Residues: 2-210; Coverage: 100%)
Gene names: Gstp1, Gstpib
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GTS 2 x GTS
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 102.1Å b: 77.6Å c: 57.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 not available
Expression system: Not provided

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Citations

6 review citations

Geometry of nonbonded interactions involving planar groups in proteins.
Chakrabarti et al. (2007)
5 more

5 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
4 more