› 1gmo

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR

Released:
DOI: 10.2210/pdb1gmo/pdb
PDB entry 1gmo coloured by chain, front view.
PDB entry 1gmo coloured by chain, side view.
PDB entry 1gmo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
Lietha D, Chirgadze DY, Mulloy B, Blundell TL, Gherardi E
EMBO J 20 5543-55 (2001)
PMID: 11597998

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Hepatocyte growth factor alpha chain Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P14210 (Residues: 28-210; Coverage: 26%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
2 bound ligands:
Ligand SO4 8 x SO4
Ligand EPE 8 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21212
Unit cell:
a: 179.7Å b: 174.1Å c: 59.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.254 0.295
Expression system: Komagataella phaffii GS115

Quick links

Citations

18 review citations

Met, metastasis, motility and more.
Birchmeier et al. (2003)
17 more

11 mentions without citation

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.
Blaszczyk et al. (2015)
10 more