› 1goe

Solution NMR

Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution in h/r Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.

Released:
DOI: 10.2210/pdb1goe/pdb
PDB entry 1goe coloured by chain, ensemble of 40 models, front view.
PDB entry 1goe coloured by chain, ensemble of 40 models, side view.
PDB entry 1goe coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Monitoring the structural consequences of Phe12-->D-Phe and Leu15-->Aib substitution in human/rat corticotropin releasing hormone. Implications for design of CRH antagonists.
Spyroulias GA, Papazacharias S, Pairas G, Cordopatis P
Eur J Biochem 269 6009-19 (2002)
PMID: 12473096

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticoliberin Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06850 (Residues: 154-194; Coverage: 24%)
Gene name: CRH
Sequence domains: Corticotropin-releasing factor family

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DPN 1 x DPN
Ligand AIB 1 x AIB

Experiments and Validation Details

Entry percentile scores
Refinement method: HYBRID DISTANCE GEOMETRY SIMULATED ANNEALING IN TORSION ANGLE SPACE
Expression system: Not provided

Quick links

Citations

4 review citations

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?
Parthier et al. (2009)
3 more

2 mentions without citation

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Li et al. (2018)
1 more