› 1gp1

X-ray diffraction
2Å resolution

THE REFINED STRUCTURE OF THE SELENOENZYME GLUTATHIONE PEROXIDASE AT 0.2-NM RESOLUTION

Released:
DOI: 10.2210/pdb1gp1/pdb
PDB entry 1gp1 coloured by chain, front view.
PDB entry 1gp1 coloured by chain, side view.
PDB entry 1gp1 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution.
Epp O, Ladenstein R, Wendel A
Eur J Biochem 133 51-69 (1983)
PMID: 6852035

Function and Biology Details

Reactions catalysed: 
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione peroxidase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 21.97 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00435 (Residues: 8-205; Coverage: 97%)
Gene name: GPX1
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SE7 2 x SE7

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 90.4Å b: 109.5Å c: 58.2Å
α: 90° β: 99° γ: 90°
R-values:
R R work R free
0.171 0.171 not available
Expression system: Not provided

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Citations

52 review citations

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.
Nordberg et al. (2001)
51 more

18 mentions without citation

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.
Golin et al. (2023)
17 more