› 1gwb

X-ray diffraction
2.8Å resolution

STRUCTURE OF GLYCOPROTEIN 1B

Released:
DOI: 10.2210/pdb1gwb/pdb
PDB entry 1gwb coloured by chain, front view.
PDB entry 1gwb coloured by chain, side view.
PDB entry 1gwb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation.
Uff S, Clemetson JM, Harrison T, Clemetson KJ, Emsley J
J Biol Chem 277 35657-63 (2002)
PMID: 12087105

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycocalicin Chains: A, B
Molecule details ›
Chains: A, B
Length: 281 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07359 (Residues: 16-296; Coverage: 44%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

4 bound ligands:
Ligand PT 4 x PT
Ligand ACY 1 x ACY
Ligand NAG 3 x NAG
Ligand SO4 1 x SO4
1 modified residue:
Ligand TYS 6 x TYS

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6422
Unit cell:
a: 202Å b: 202Å c: 128Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.245 0.245 0.274

Quick links

Citations

25 review citations

Leucine-rich repeats and pathogen recognition in Toll-like receptors.
Bell et al. (2003)
24 more

6 mentions without citation

Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations.
Savoia et al. (2011)
5 more