› 1gwq

X-ray diffraction
2.45Å resolution

HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE

Released:
DOI: 10.2210/pdb1gwq/pdb
PDB entry 1gwq coloured by chain, front view.
PDB entry 1gwq coloured by chain, side view.
PDB entry 1gwq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha.
Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC
J Biol Chem 277 21862-8 (2002)
PMID: 11937504

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136928 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 28.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 301-548; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 688-696; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand ZTW 2 x ZTW
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 54.82Å b: 63.62Å c: 74.72Å
α: 90° β: 98.34° γ: 90°
R-values:
R R work R free
0.206 0.206 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

13 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
12 more

16 mentions without citation

Chemistry and structural biology of androgen receptor.
Gao et al. (2005)
15 more