› 1h3h

Solution NMR

Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain

Released:
DOI: 10.2210/pdb1h3h/pdb
PDB entry 1h3h coloured by chain, ensemble of 20 models, front view.
PDB entry 1h3h coloured by chain, ensemble of 20 models, side view.
PDB entry 1h3h coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition.
Liu Q, Berry D, Nash P, Pawson T, McGlade CJ, Li SS
Mol Cell 11 471-81 (2003)
PMID: 12620234

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131611 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GRB2-related adaptor protein 2 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.95 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O89100 (Residues: 263-322; Coverage: 19%)
Gene names: Gads, Grap2, Grb2l, Grid, Mona
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Lymphocyte cytosolic protein 2 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13094 (Residues: 232-241; Coverage: 2%)
Gene name: LCP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MDSA
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Structure and regulation of Src family kinases.
Boggon et al. (2004)
18 more

3 mentions without citation

A proposed syntax for Minimotif Semantics, version 1.
Vyas et al. (2009)
2 more