› 1h4r

X-ray diffraction
1.8Å resolution

Crystal Structure of the FERM domain of Merlin, the Neurofibromatosis 2 Tumor Suppressor Protein.

Released:
DOI: 10.2210/pdb1h4r/pdb
PDB entry 1h4r coloured by chain, front view.
PDB entry 1h4r coloured by chain, side view.
PDB entry 1h4r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product.
Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS
Acta Crystallogr D Biol Crystallogr 58 381-91 (2002)
PMID: 11856822

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Merlin Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 36.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35240 (Residues: 1-313; Coverage: 53%)
Gene names: NF2, SCH
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 87.018Å b: 89.328Å c: 96.764Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

ERM proteins and merlin: integrators at the cell cortex.
Bretscher et al. (2002)
8 more

13 mentions without citation

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan et al. (2010)
12 more