› 1he7

X-ray diffraction
2Å resolution

Human Nerve growth factor receptor TrkA

Released:
DOI: 10.2210/pdb1he7/pdb
PDB entry 1he7 coloured by chain, front view.
PDB entry 1he7 coloured by chain, side view.
PDB entry 1he7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification and structure of the nerve growth factor binding site on TrkA.
Robertson AG, Banfield MJ, Allen SJ, Dando JA, Mason GG, Tyler SJ, Bennett GS, Brain SD, Clarke AR, Naylor RL, Wilcock GK, Brady RL, Dawbarn D
Biochem Biophys Res Commun 282 131-41 (2001)
PMID: 11263982

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04629 (Residues: 285-413; Coverage: 16%)
Gene names: MTC, NTRK1, TRK, TRKA
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P4322
Unit cell:
a: 50.854Å b: 50.854Å c: 107.808Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.276
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Trk receptors: roles in neuronal signal transduction.
Huang et al. (2003)
2 more

8 mentions without citation

Linking in domain-swapped protein dimers.
Baiesi et al. (2016)
7 more