› 1hij

X-ray diffraction
3Å resolution

INTERLEUKIN-4 MUTANT WITH ARG 88 REPLACED WITH GLN (R88Q)

Released:
DOI: 10.2210/pdb1hij/pdb
PDB entry 1hij coloured by chain, front view.
PDB entry 1hij coloured by chain, side view.
PDB entry 1hij coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
Müller T, Oehlenschläger F, Buehner M
J Mol Biol 247 360-72 (1995)
PMID: 7707380

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 92.1Å b: 92.1Å c: 46.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.316
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Interleukin-6: structure-function relationships.
Simpson et al. (1997)
3 more

3 mentions without citation

Recent Force Field Strategies for Intrinsically Disordered Proteins.
Mu et al. (2021)
2 more