› 1hk2

X-ray diffraction
2.8Å resolution

HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)

Released:
DOI: 10.2210/pdb1hk2/pdb
PDB entry 1hk2 coloured by chain, front view.
PDB entry 1hk2 coloured by chain, side view.
PDB entry 1hk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia.
Petitpas I, Petersen CE, Ha CE, Bhattacharya AA, Zunszain PA, Ghuman J, Bhagavan NV, Curry S
Proc Natl Acad Sci U S A 100 6440-5 (2003)
PMID: 12743361

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.55 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand T44 4 x T44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21
Unit cell:
a: 58.942Å b: 88.391Å c: 59.992Å
α: 90° β: 103° γ: 90°
R-values:
R R work R free
0.19 0.19 0.244
Expression system: Komagataella pastoris

Quick links

Citations

21 review citations

The extraordinary ligand binding properties of human serum albumin.
Fasano et al. (2005)
20 more

3 mentions without citation

Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia.
Kragh-Hansen et al. (2017)
2 more