› 1hp7

X-ray diffraction
2.1Å resolution

A 2.1 ANGSTROM STRUCTURE OF AN UNCLEAVED ALPHA-1-ANTITRYPSIN SHOWS VARIABILITY OF THE REACTIVE CENTER AND OTHER LOOPS

Released:
DOI: 10.2210/pdb1hp7/pdb
PDB entry 1hp7 coloured by chain, front view.
PDB entry 1hp7 coloured by chain, side view.
PDB entry 1hp7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops.
Kim S, Woo J, Seo EJ, Yu M, Ryu S
J Mol Biol 306 109-19 (2001)
PMID: 11178897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 25-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 5 x ZN
Ligand BME 1 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3212
Unit cell:
a: 77.57Å b: 77.57Å c: 124.29Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.219 0.273
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology.
Lomas et al. (2004)
4 more

19 mentions without citation

Update of the human and mouse SERPIN gene superfamily.
Heit et al. (2013)
18 more