› 1hrn

X-ray diffraction
1.8Å resolution

HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS

Released:
DOI: 10.2210/pdb1hrn/pdb
PDB entry 1hrn coloured by chain, front view.
PDB entry 1hrn coloured by chain, side view.
PDB entry 1hrn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G
J Mol Biol 250 211-22 (1995)
PMID: 7608971

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: A, B
Molecule details ›
Chains: A, B
Length: 337 amino acids
Theoretical weight: 36.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 70-406; Coverage: 88%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand 03D 2 x 03D
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P213
Unit cell:
a: 141.1Å b: 141.1Å c: 141.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 not available
Expression system: Not provided

Quick links

Citations

10 citation in other articles

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.
Rahuel et al. (2000)
9 more

9 mentions without citation

Effects of Glycosylation on the Enzymatic Activity and Mechanisms of Proteases.
Goettig P. (2016)
8 more