› 1hrz

Solution NMR

THE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTI-DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR

Released:
DOI: 10.2210/pdb1hrz/pdb
PDB entry 1hrz coloured by chain, ensemble of 35 models, front view.
PDB entry 1hrz coloured by chain, ensemble of 35 models, side view.
PDB entry 1hrz coloured by chain, ensemble of 35 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex.
Werner MH, Huth JR, Gronenborn AM, Clore GM
Cell 81 705-14 (1995)
PMID: 7774012

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113909 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Sex-determining region Y protein Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 9.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q05066 (Residues: 56-131; Coverage: 37%)
Gene names: SRY, TDF
Sequence domains: HMG (high mobility group) box
Structure domains: High mobility group box domain
DNA (5'-D(*GP*CP*AP*CP*AP*AP*AP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 8 nucleotides
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*GP*TP*TP*TP*GP*TP*GP*C)-3') Chain: C
Molecule details ›
Chain: C
Length: 8 nucleotides
Theoretical weight: 2.45 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

58 review citations

Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins.
Bustin M. (1999)
57 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more