› 1hso

X-ray diffraction
2.5Å resolution

HUMAN ALPHA ALCOHOL DEHYDROGENASE (ADH1A)

Released:
DOI: 10.2210/pdb1hso/pdb
PDB entry 1hso coloured by chain, front view.
PDB entry 1hso coloured by chain, side view.
PDB entry 1hso coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structures of the three human class I alcohol dehydrogenases.
Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD
Protein Sci 10 697-706 (2001)
PMID: 11274460

Function and Biology Details

Reaction catalysed: 
A primary alcohol + NAD(+) = an aldehyde + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alcohol dehydrogenase 1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 374 amino acids
Theoretical weight: 39.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07327 (Residues: 2-375; Coverage: 100%)
Gene names: ADH1, ADH1A
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
2 bound ligands:
Ligand ZN 4 x ZN
Ligand PYZ 2 x PYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 55.7Å b: 100.2Å c: 69.1Å
α: 90° β: 104.9° γ: 90°
R-values:
R R work R free
0.194 0.248 0.191
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations.
Peng et al. (2009)
10 more

5 mentions without citation

Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study.
Yang et al. (2011)
4 more