› 1hup

X-ray diffraction
2.5Å resolution

HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL

Released:
DOI: 10.2210/pdb1hup/pdb
PDB entry 1hup coloured by chain, front view.
PDB entry 1hup coloured by chain, side view.
PDB entry 1hup coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil.
Sheriff S, Chang CY, Ezekowitz RA
Nat. Struct. Biol. 1 789-94 (1994)
PMID: 7634089

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mannose-binding protein C Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 15.63 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P11226 (Residues: 108-248; Coverage: 62%)
Gene names: COLEC1, MBL, MBL2
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P321
Unit cell:
a: 76.68Å b: 76.68Å c: 58.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.199 not available
Expression system: Mus musculus

Quick links

Citations

41 review citations

The C-type lectin superfamily in the immune system.
Weis et al. (1998)
40 more

15 mentions without citation

Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs.
Gupta et al. (2021)
14 more