› 1hzm

Solution NMR

STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2

Released:
DOI: 10.2210/pdb1hzm/pdb
PDB entry 1hzm coloured by chain, front view.
PDB entry 1hzm coloured by chain, side view.
PDB entry 1hzm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM
Mol Cell 7 387-99 (2001)
PMID: 11239467

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172588 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase 6 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16828 (Residues: 1-154; Coverage: 40%)
Gene names: DUSP6, MKP3, PYST1
Sequence domains: Rhodanese-like domain
Structure domains: Rhodanese-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.
Owens et al. (2007)
19 more

9 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
8 more