› 1i09

X-ray diffraction
2.7Å resolution

STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B)

Released:
DOI: 10.2210/pdb1i09/pdb
PDB entry 1i09 coloured by chain, front view.
PDB entry 1i09 coloured by chain, side view.
PDB entry 1i09 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of GSK3beta reveals a primed phosphorylation mechanism.
ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J
Nat Struct Biol 8 593-6 (2001)
PMID: 11427888

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 83.272Å b: 86.725Å c: 177.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.274
Expression system: unidentified baculovirus

Quick links

Citations

62 review citations

AKT/PKB Signaling: Navigating the Network.
Manning et al. (2017)
61 more

19 mentions without citation

Developing irreversible inhibitors of the protein kinase cysteinome.
Liu et al. (2013)
18 more