› 1i1j

X-ray diffraction
1.39Å resolution

STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS

Released:
DOI: 10.2210/pdb1i1j/pdb
PDB entry 1i1j coloured by chain, front view.
PDB entry 1i1j coloured by chain, side view.
PDB entry 1i1j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.
Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM
Proc Natl Acad Sci U S A 98 5515-20 (2001)
PMID: 11331761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoma-derived growth regulatory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16674 (Residues: 25-131; Coverage: 100%)
Gene name: MIA
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2, SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 47.534Å b: 48.396Å c: 87.774Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.231
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Protein export at the ER: loading big collagens into COPII carriers.
Malhotra et al. (2011)
2 more

9 mentions without citation

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.
Lougheed et al. (2001)
8 more