› 1i4w

X-ray diffraction
2.6Å resolution

THE CRYSTAL STRUCTURE OF THE TRANSCRIPTION FACTOR SC-MTTFB OFFERS INTRIGUING INSIGHTS INTO MITOCHONDRIAL TRANSCRIPTION

Released:
DOI: 10.2210/pdb1i4w/pdb
PDB entry 1i4w coloured by chain, front view.
PDB entry 1i4w coloured by chain, side view.
PDB entry 1i4w coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription.
Schubot FD, Chen CJ, Rose JP, Dailey TA, Dailey HA, Wang BC
Protein Sci 10 1980-8 (2001)
PMID: 11567089

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial transcription factor 1 Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 41.09 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P14908 (Residues: 2-341; Coverage: 100%)
Gene names: MTF1, YM9959.10, YMR228W
Sequence domains: Ribosomal RNA adenine dimethylase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand XE 3 x XE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 90.418Å b: 44.684Å c: 99.819Å
α: 90° β: 110.23° γ: 90°
R-values:
R R work R free
0.191 0.187 0.274
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Scarpulla RC. (2008)
8 more

17 mentions without citation

Structural basis of mitochondrial transcription.
Hillen et al. (2018)
16 more