› 1i8h

Solution NMR

SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH HUMAN TAU PHOSPHOTHREONINE PEPTIDE

Released:
DOI: 10.2210/pdb1i8h/pdb
PDB entry 1i8h coloured by chain, ensemble of 10 models, front view.
PDB entry 1i8h coloured by chain, ensemble of 10 models, side view.
PDB entry 1i8h coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides.
Wintjens R, Wieruszeski JM, Drobecq H, Rousselot-Pailley P, Buée L, Lippens G, Landrieu I
J Biol Chem 276 25150-6 (2001)
PMID: 11313338

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145372 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 542-554; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: B
Molecule details ›
Chain: B
Length: 39 amino acids
Theoretical weight: 4.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13526 (Residues: 6-44; Coverage: 24%)
Gene name: PIN1
Sequence domains: WW domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

11 review citations

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease.
Lu et al. (2007)
10 more

11 mentions without citation

Intracerebral propagation of Alzheimer's disease: strengthening evidence of a herpes simplex virus etiology.
Ball et al. (2013)
10 more