› 1iam

X-ray diffraction
2.1Å resolution

STRUCTURE OF THE TWO AMINO-TERMINAL DOMAINS OF HUMAN INTERCELLULAR ADHESION MOLECULE-1, ICAM-1

Released:
DOI: 10.2210/pdb1iam/pdb
PDB entry 1iam coloured by chain, front view.
PDB entry 1iam coloured by chain, side view.
PDB entry 1iam coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.
Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG
Proc Natl Acad Sci U S A 95 4140-5 (1998)
PMID: 9539703

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138635 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intercellular adhesion molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05362 (Residues: 28-212; Coverage: 37%)
Gene name: ICAM1
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2221
Unit cell:
a: 41.857Å b: 124.736Å c: 83.186Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.303
Expression system: Spodoptera frugiperda

Quick links

Citations

31 review citations

Conformational regulation of integrin structure and function.
Shimaoka et al. (2002)
30 more

22 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
21 more