› 1ias

X-ray diffraction
2.9Å resolution

CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12

Released:
DOI: 10.2210/pdb1ias/pdb
PDB entry 1ias coloured by chain, front view.
PDB entry 1ias coloured by chain, side view.
PDB entry 1ias coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.
Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J
Mol Cell 8 671-82 (2001)
PMID: 11583628

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 342 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 15 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2221
Unit cell:
a: 172.56Å b: 251.617Å c: 140.228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.255 0.284
Expression system: Spodoptera frugiperda

Quick links

Citations

101 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
100 more

15 mentions without citation

Protein Kinase Targets in Breast Cancer.
García-Aranda et al. (2017)
14 more