› 1igr

X-ray diffraction
2.6Å resolution

Type 1 Insulin-like growth factor receptor (DOMAINS 1-3)

Released:
DOI: 10.2210/pdb1igr/pdb
PDB entry 1igr coloured by chain, front view.
PDB entry 1igr coloured by chain, side view.
PDB entry 1igr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.
Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW
Nature 394 395-9 (1998)
PMID: 9690478

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Insulin-like growth factor 1 receptor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 478 amino acids
Theoretical weight: 54.39 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-492; Coverage: 35%)
Gene name: IGF1R
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18X
Spacegroup: P212121
Unit cell:
a: 77.39Å b: 99.72Å c: 120.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.304
Expression system: Cricetulus griseus

Quick links

Citations

39 review citations

The role of the IGF system in cancer growth and metastasis: overview and recent insights.
Samani et al. (2007)
38 more

22 mentions without citation

Insulin and epidermal growth factor receptor family members share parallel activation mechanisms.
Ferguson et al. (2020)
21 more