› 1ihk

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)

Released:
DOI: 10.2210/pdb1ihk/pdb
PDB entry 1ihk coloured by chain, front view.
PDB entry 1ihk coloured by chain, side view.
PDB entry 1ihk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
Plotnikov AN, Eliseenkova AV, Ibrahimi OA, Shriver Z, Sasisekharan R, Lemmon MA, Mohammadi M
J Biol Chem 276 4322-9 (2001)
PMID: 11060292

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151993 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 9 Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31371 (Residues: 35-208; Coverage: 84%)
Gene name: FGF9
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I4122
Unit cell:
a: 87.823Å b: 87.823Å c: 115.636Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.226
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Structural basis for fibroblast growth factor receptor activation.
Mohammadi et al. (2005)
8 more

16 mentions without citation

Exploring mechanisms of FGF signalling through the lens of structural biology.
Goetz et al. (2013)
15 more