› 1ii4

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2

Released:
DOI: 10.2210/pdb1ii4/pdb
PDB entry 1ii4 coloured by chain, front view.
PDB entry 1ii4 coloured by chain, side view.
PDB entry 1ii4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Ibrahimi OA, Eliseenkova AV, Plotnikov AN, Yu K, Ornitz DM, Mohammadi M
Proc Natl Acad Sci U S A 98 7182-7 (2001)
PMID: 11390973

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140534 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 155 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09038 (Residues: 134-288; Coverage: 54%)
Gene names: FGF2, FGFB
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor receptor 2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 220 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 147-366; Coverage: 28%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 70.97Å b: 72.657Å c: 89.739Å
α: 89.98° β: 89.7° γ: 90°
R-values:
R R work R free
0.238 0.238 0.267
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Cellular signaling by fibroblast growth factor receptors.
Eswarakumar et al. (2005)
34 more

6 mentions without citation

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Ibrahimi et al. (2001)
5 more