› 1ikf

X-ray diffraction
2.5Å resolution

A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX

Released:
DOI: 10.2210/pdb1ikf/pdb
PDB entry 1ikf coloured by chain, front view.
PDB entry 1ikf coloured by chain, side view.
PDB entry 1ikf coloured by chain, top view.
Source organisms:
Primary publication:
A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex.
Altschuh D, Vix O, Rees B, Thierry JC
Science 256 92-4 (1992)
PMID: 1566062

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211560 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IGG1-KAPPA R45-45-11 FAB (LIGHT CHAIN) Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
IGG1-KAPPA R45-45-11 FAB (HEAVY CHAIN) Chain: H
Molecule details ›
Chain: H
Length: 228 amino acids
Theoretical weight: 24.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
CYCLOSPORIN A Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 1 x DAL
Ligand MLE 4 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand ABA 1 x ABA
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 52.6Å b: 70.2Å c: 118.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.164 not available
Expression system: Not provided

Quick links

Citations

14 review citations

Anatomy of the antibody molecule.
Padlan EA. (1994)
13 more

12 mentions without citation

Quantitative prediction of protein-protein binding affinity with a potential of mean force considering volume correction.
Su et al. (2009)
11 more