› 1inx

X-ray diffraction
2.4Å resolution

A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

Released:
DOI: 10.2210/pdb1inx/pdb
PDB entry 1inx coloured by chain, front view.
PDB entry 1inx coloured by chain, side view.
PDB entry 1inx coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
White CL, Janakiraman MN, Laver WG, Philippon C, Vasella A, Air GM, Luo M
J Mol Biol 245 623-34 (1995)
PMID: 7844831

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139245 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 43.14 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: P06820 (Residues: 82-469; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand NAG 3 x NAG
Ligand CA 1 x CA
Ligand EQP 1 x EQP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 120.42Å b: 139.83Å c: 140.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Roles for glycosylation of cell surface receptors involved in cellular immune recognition.
Rudd et al. (1999)
8 more

4 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
3 more