› 1iqb

X-ray diffraction
1.9Å resolution

Crystal Structure of Urtica dioica Agglutinin Isolectin I

Released:
DOI: 10.2210/pdb1iqb/pdb
PDB entry 1iqb coloured by chain, front view.
PDB entry 1iqb coloured by chain, side view.
PDB entry 1iqb coloured by chain, top view.
Source organism: Urtica dioica
Primary publication:
Structure of Urtica dioica agglutinin isolectin I: dimer formation mediated by two zinc ions bound at the sugar-binding site.
Harata K, Schubert WD, Muraki M
Acta Crystallogr D Biol Crystallogr 57 1513-7 (2001)
PMID: 11679714

Function and Biology Details

Reaction catalysed: 
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lectin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.41 KDa
Source organism: Urtica dioica
UniProt:
  • Canonical: P11218 (Residues: 24-112; Coverage: 26%)
Gene name: UDA1
Sequence domains: Chitin recognition protein

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P21
Unit cell:
a: 30.71Å b: 42.11Å c: 62.59Å
α: 90° β: 101.55° γ: 90°
R-values:
R R work R free
0.205 0.205 0.26

Quick links

Citations

2 review citations

Inhibition of HIV entry by carbohydrate-binding proteins.
Balzarini J. (2006)
1 more

1 mention without citation

Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain.
Wang et al. (2015)