Function and Biology Details
Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134410 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-1 beta
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Length: 153 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P01584 (Residues: 117-269; Coverage: 57%)
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Interleukin-1 receptor type 1, soluble form
Molecule details ›
Chain: B
Length: 315 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 315 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P14778 (Residues: 18-332; Coverage: 57%)
Sequence domains:
Structure domains: Immunoglobulins
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RUH3R
Spacegroup:
C2
Expression system: Escherichia coli
