› 1itf

Solution NMR

INTERFERON ALPHA-2A, NMR, 24 STRUCTURES

Released:
DOI: 10.2210/pdb1itf/pdb
PDB entry 1itf coloured by chain, ensemble of 24 models, front view.
PDB entry 1itf coloured by chain, ensemble of 24 models, side view.
PDB entry 1itf coloured by chain, ensemble of 24 models, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.
Klaus W, Gsell B, Labhardt AM, Wipf B, Senn H
J Mol Biol 274 661-75 (1997)
PMID: 9417943

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 19.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01563 (Residues: 24-188; Coverage: 100%)
Gene names: IFNA2, IFNA2A, IFNA2B, IFNA2C
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Interferons, interferon-like cytokines, and their receptors.
Pestka et al. (2004)
14 more

19 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
18 more