› 1iyt

Solution NMR

Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)

Released:
DOI: 10.2210/pdb1iyt/pdb
PDB entry 1iyt coloured by chain, ensemble of 10 models, front view.
PDB entry 1iyt coloured by chain, ensemble of 10 models, side view.
PDB entry 1iyt coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
Crescenzi O, Tomaselli S, Guerrini R, Salvadori S, D'Ursi AM, Temussi PA, Picone D
Eur J Biochem 269 5642-8 (2002)
PMID: 12423364

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)
Structure domains: Amyloidogenic glycoprotein, amyloid-beta peptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics and restrained minimization
Expression system: Not provided

Quick links

Citations

25 review citations

Amyloid-beta aggregation.
Finder et al. (2007)
24 more

135 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
134 more