› 1j38

X-ray diffraction
2.6Å resolution

Crystal Structure of Drosophila AnCE

Released:
DOI: 10.2210/pdb1j38/pdb
PDB entry 1j38 coloured by chain, front view.
PDB entry 1j38 coloured by chain, side view.
PDB entry 1j38 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril.
Kim HM, Shin DR, Yoo OJ, Lee H, Lee JO
FEBS Lett 538 65-70 (2003)
PMID: 12633854

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensin-converting enzyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 607 amino acids
Theoretical weight: 70.44 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q10714 (Residues: 14-615; Coverage: 100%)
Gene names: Ance, CG8827, Race
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 94.912Å b: 121.223Å c: 94.74Å
α: 90° β: 99.39° γ: 90°
R-values:
R R work R free
0.246 0.246 0.281
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

Angiotensin-I-converting enzyme and its relatives.
Riordan JF. (2003)
16 more

1 mention without citation

Structure of testis ACE glycosylation mutants and evidence for conserved domain movement.
Watermeyer et al. (2006)