› 1j4n

X-ray diffraction
2.2Å resolution

Crystal Structure of the AQP1 water channel

Released:
DOI: 10.2210/pdb1j4n/pdb
PDB entry 1j4n coloured by chain, front view.
PDB entry 1j4n coloured by chain, side view.
PDB entry 1j4n coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural basis of water-specific transport through the AQP1 water channel.
Sui H, Han BG, Lee JK, Walian P, Jap BK
Nature 414 872-8
PMID: 11780053

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-155663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-1 Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 28.82 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P47865 (Residues: 1-271; Coverage: 100%)
Gene name: AQP1
Sequence domains: Major intrinsic protein
Structure domains: Glycerol uptake facilitator protein.

Ligands and Environments

1 bound ligand:
Ligand BNG 3 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: I422
Unit cell:
a: 93.331Å b: 93.331Å c: 180.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.266 0.308

Quick links

Citations

124 review citations

Aquaporin water channels--from atomic structure to clinical medicine.
Agre et al. (2002)
123 more

106 mentions without citation

Aquaporins: important but elusive drug targets.
Verkman et al. (2014)
105 more