› 1j4w

Solution NMR

COMPLEX OF THE KH3 and KH4 DOMAINS OF FBP WITH A SINGLE_STRANDED 29mer DNA OLIGONUCLEOTIDE FROM THE FUSE ELEMENT OF THE C-MYC ONCOGENE

Released:
DOI: 10.2210/pdb1j4w/pdb
PDB entry 1j4w coloured by chain, front view.
PDB entry 1j4w coloured by chain, side view.
PDB entry 1j4w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of KH domains from FBP bound to single-stranded DNA.
Braddock DT, Louis JM, Baber JL, Levens D, Clore GM
Nature 415 1051-6 (2002)
PMID: 11875576

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113987 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Far upstream element-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 18.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96AE4 (Residues: 278-447; Coverage: 26%)
Gene name: FUBP1
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
DNA (5'-D(*GP*TP*A*TP*AP*TP*TP*CP*CP*CP*TP*CP*GP*GP*G*AP*TP*TP*TP*TP*TP*TP*AP*TP*TP*TP*TP*GP*T)-3') Chain: B
Molecule details ›
Chain: B
Length: 29 nucleotides
Theoretical weight: 8.88 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

16 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
15 more

8 mentions without citation

Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.
Briata et al. (2016)
7 more