› 1j7t

X-ray diffraction
2.5Å resolution

Complex between Paromomycin and the 16S-rRNA A-site at 2.5 A resolution

Released:
DOI: 10.2210/pdb1j7t/pdb
PDB entry 1j7t coloured by chain, front view.
PDB entry 1j7t coloured by chain, side view.
PDB entry 1j7t coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site.
Vicens Q, Westhof E
Structure 9 647-58 (2001)
PMID: 11587639

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196062 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 22 nucleotides
Theoretical weight: 7.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PAR 2 x PAR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 33Å b: 45.9Å c: 95.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.247
Expression system: Not provided

Quick links

Citations

39 review citations

Structural insights into translational fidelity.
Ogle et al. (2005)
38 more

26 mentions without citation

Recent Advances in Developing Small Molecules Targeting Nucleic Acid.
Wang et al. (2016)
25 more