› 1j8e

X-ray diffraction
1.85Å resolution

Crystal structure of ligand-binding repeat CR7 from LRP

Released:
DOI: 10.2210/pdb1j8e/pdb
PDB entry 1j8e coloured by chain, front view.
PDB entry 1j8e coloured by chain, side view.
PDB entry 1j8e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor.
Simonovic M, Dolmer K, Huang W, Strickland DK, Volz K, Gettins PG
Biochemistry 40 15127-34 (2001)
PMID: 11735395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor-related protein 1 515 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 4.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07954 (Residues: 1011-1054; Coverage: 1%)
Gene names: A2MR, APR, LRP1
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 27.588Å b: 35.359Å c: 36.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
5 more

4 mentions without citation

Structural basis for complement factor I control and its disease-associated sequence polymorphisms.
Roversi et al. (2011)
3 more