› 1jbi

Solution NMR

NMR structure of the LCCL domain

Released:
DOI: 10.2210/pdb1jbi/pdb
PDB entry 1jbi coloured by chain, ensemble of 20 models, front view.
PDB entry 1jbi coloured by chain, ensemble of 20 models, side view.
PDB entry 1jbi coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the LCCL domain and implications for DFNA9 deafness disorder.
Liepinsh E, Trexler M, Kaikkonen A, Weigelt J, Bányai L, Patthy L, Otting G
EMBO J 20 5347-53 (2001)
PMID: 11574466

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cochlin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43405 (Residues: 27-126; Coverage: 19%)
Gene names: COCH, COCH5B2, UNQ257/PRO294
Sequence domains: LCCL domain
Structure domains: LCCL-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics,simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The role of the posterior ciliary body in the biosynthesis of vitreous humour.
Bishop et al. (2002)
4 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)