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Crystal Structure of Native Methylmalonyl-CoA Epimerase

Source organism: Propionibacterium freudenreichii subsp. shermanii
Biochemical function: metal ion binding
Biological process: L-methylmalonyl-CoA metabolic process
Cellular component: not assigned

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EC 5.1.99.1: Methylmalonyl-CoA epimerase

Reaction catalysed:
(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
Systematic name:
Methylmalonyl-CoA 2-epimerase
Alternative Name(s):
  • 2-methyl-3-oxopropanoyl-CoA 2-epimerase
  • DL-methylmalonyl-CoA racemase
  • Methylmalonyl coenzyme A racemase
  • Methylmalonyl-CoA racemase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13669
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 1jc5 contains 6 copies of Pfam domain PF13669 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in VOC domain-containing protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR017515
Domain description: Methylmalonyl-CoA epimerase
Occurring in:
  1. VOC domain-containing protein
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. VOC domain-containing protein
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. VOC domain-containing protein

Structure domain

CATH CATH domain
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 1jc5 contains 6 copies of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in VOC domain-containing protein. Showing 1 copy in chain B.
SCOP SCOP annotation
64257
Class: Alpha and beta proteins (a+b)
Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. VOC domain-containing protein
The deposited structure of PDB entry 1jc5 contains 6 copies of SCOP domain 64257 (Methylmalonyl-CoA epimerase) in VOC domain-containing protein. Showing 1 copy in chain B.

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