› 1jdn

X-ray diffraction
2.9Å resolution

Crystal Structure of Hormone Receptor

Released:
DOI: 10.2210/pdb1jdn/pdb
PDB entry 1jdn coloured by chain, front view.
PDB entry 1jdn coloured by chain, side view.
PDB entry 1jdn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.
Martick MM, Garcia KC
Science 293 1657-62 (2001)
PMID: 11533490

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Atrial natriuretic peptide receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 441 amino acids
Theoretical weight: 49.54 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P17342 (Residues: 44-485; Coverage: 86%)
Gene names: ANPRC, C5orf23, NPR3, NPRC
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P6122
Unit cell:
a: 217.189Å b: 217.189Å c: 130.793Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.243 0.256
Expression system: Drosophila melanogaster

Quick links

Citations

40 review citations

Coupling of folding and binding for unstructured proteins.
Dyson et al. (2002)
39 more

8 mentions without citation

Photoreceptor guanylate cyclase variants: cGMP production under control.
Sokal et al. (2003)
7 more